Tyro3 is a key regulator of myelin structure and retinal function in the central nervous system

Abstract

Background: While it is evident how critical myelin is for neural signalling in the CNS, the biological processes underpinning myelination remain unknown. Previously, we have shown that the receptor tyrosine kinase, Tyro3, regulates developmental myelination and myelin thickness in the CNS. Objectives: The aim of this study was to extend on our previous data by assessing the role of Tyro3 in regulating other myelin structures such as the node of Ranvier; and to assess the effect of Tyro3 loss on axonal conductivity and retinal function. Methods: To investigate node of Ranvier microstructure, we used electron microscopy and manually assessed paranodal loops. We measured nodal and paranodal ..